What does Nikolsky sign indicate?
The Nikolsky sign is dislodgement of intact superficial epidermis by a shearing force, indicating a plane of cleavage in the skin epidermal-epidermal junctions (e.g., desmosomes).
Does bullous pemphigoid have a positive Nikolsky sign?
Bullous Pemphigoid The lesions of BP initially arise as tense intact vesicles. Nikolsky’s sign is usually negative.
How can you tell the difference between pemphigus and pemphigoid?
Pemphigus is characterized by shallow ulcers or fragile blisters that break open quickly.
Does Lichen Planus have a positive Nikolsky sign?
Oral lichen planus is a chronic inflammatory mucocutaneous disease caused by an unknown etiology. A possible autoimmune etiology has been suggested but not yet confirmed in lichen planus. Nonetheless, a positive Nikolsky’s sign sometimes was identified in patients with erosive oral lichen planus (Figure 7) [40, 41].
Does mucous membrane pemphigoid have positive Nikolsky sign?
Positive Nikolsky’s sign can be observed in the mucosa as well as in the mucous membrane pemphigoid in addition to pemphigus vulgaris, and vesiculobullous lesions should be diagnosed based on the sum of clinical, histopathological, and immunofluorescence findings.
What is pemphigus Vegetans?
Pemphigus vegetans is a rare variant of pemphigus vulgaris characterized by heaped up, cauliflower-like vegetating plaques in the flexures. [1] The disorder affects chiefly middle-aged adults. Lesions are primarily flexural, although vegetations may occur at any site.
What are the different types of pemphigus?
Types of Pemphigus
- Pemphigus Vulgaris. This is the most common form of pemphigus.
- Pemphigus Foliaceus. Pemphigus foliaceus is another common form of pemphigus.
- Pemphigus Vegetans.
- IgA Pemphigus.
- Paraneoplastic Pemphigus.
- Further Reading.
Is bullous pemphigoid a type of pemphigus?
Bullous pemphigoid usually involves pruritic bullae and/or urticarial plaques that occur most commonly in the groin, axillae, and flexural areas. Unlike pemphigus, involvement of the oropharyngeal mucosa occurs in only 1/3 of cases. It generally occurs as a more sudden widespread eruption, compared to pemphigus.
What are Wickham striae?
The term Wickham striae (WS) was coined by Louis Frédéric Wickham in the year 1895 and corresponds to fine white or gray lines or dots seen on the top of the papular rash and oral mucosal lesions of Lichen planus (LP),[1] also called as Lichen Ruber Planus.
How can you tell the difference between SJS and 10?
The difference between SJS, SJS/TEN overlap, and TEN is defined by the degree of skin detachment: SJS is defined as skin involvement of < 10%, TEN is defined as skin involvement of > 30%, and SJS/TEN overlap as 10-30% skin involvement.
What is pemphigoid in the eye?
Ocular mucous membrane pemphigoid is a chronic, bilateral, progressive scarring and shrinkage of the conjunctiva with opacification of the cornea. Early symptoms are hyperemia and irritation; progression leads to eyelid and corneal damage and sometimes blindness. Diagnosis is sometimes confirmed by biopsy.
